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Clinical Trial Study to be Conducted at UPMC Hillman Cancer to Evaluate Novel Combination as Frontline TherapyCHICAGO and FORT WORTH, Texas, Aug. 06, 2025 (GLOBE NEWSWIRE) -- Actuate Therapeutics, Inc. (NASDAQ:ACTU)
08-06 20:47
Actuate Therapeutics initiates a Phase 1b trial of elraglusib in combination with Incyte’s PD-1 inhibitor retifanlimab and modified FOLFIRINOX as frontline therapy for advanced pancreatic adenocarcinoma. Conducted at UPMC Hillman Cancer Center, the trial aims to determine the recommended phase 2 dose (RP2D) and evaluate efficacy, safety, and tolerability. Anwaar Saeed, MD, highlights elraglusib’s potential to enhance immune responses and modulate...
08-06 12:45
Actuate Therapeutics shares are trading higher after the company announced it w...
07-17 21:23
Actuate Therapeutics has completed Phase 1 of its elraglusib study in pediatric patients with refractory malignancies, showing promising results in treating Ewing Sarcoma (EWS). Among ten EWS patients, two achieved complete responses, two had stable disease, and one patient with desmoplastic small-round-cell tumor (DSRCT) saw a partial response. Actuate plans to initiate a Phase 2 trial in 2026 for relapsed/refractory EWS patients, targeting both...
07-17 12:45
- Near doubling of 1-year overall survival (OS), increased median OS of 4 months (12.5 vs 8.5 months), and 43% reduction in risk of death in patients treated with at least one cycle (4 weeks) of elraglusib plus
06-24 21:22
Actuate Therapeutics reported Phase 2 trial results for elraglusib in combination with gemcitabine/nab-paclitaxel (GnP) in first-line metastatic pancreatic adenocarcinoma (mPDAC). Patients receiving at least one cycle of elraglusib/GnP achieved a median overall survival (mOS) of 12.5 months vs 8.5 months in the control arm, with a 43% reduction in death risk. Liver metastases patients saw a 2.5-fold improvement in 1-year OS and 38% reduced death ...
06-24 13:15
Inclusion reflects continued growth and momentum in the company's mission to transform the treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)CHICAGO and FORT WORTH, Texas, June 16, 2025 (GLOBE NEWSWIRE) --
06-16 20:31
Actuate Therapeutics has been added to the Russell 3000® and Russell 2000® Indexes, reflecting its growth and recent positive Phase 2 data for elraglusib in mPDAC, showing improved survival rates. This inclusion enhances the company's visibility and validates its platform for long-term growth.
06-16 12:30
Actuate Therapeutics announced positive results from its Phase 2 clinical trial of elraglusib combined with gemcitabine/nab-paclitaxel in untreated metastatic pancreatic ductal adenocarcinoma patients. The trial met its primary endpoint, showing a 10.1-month median overall survival (mOS) vs 7.2 months with GnP alone (p=0.01), a 37% reduced risk of death (HR=0.63). Twelve-month survival rates doubled to 44.1% in the elraglusib group. The event fea...
06-02 13:00
Actuate Therapeutics (NASDAQ:ACTU) on Saturday announced encouraging results from a Phase 2 clinical trial testing its experimental cancer drug, elraglusib, in combination with standard chemotherapy i...
06-01 04:57