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Viridian疗法称REVEAL-1研究符合甲状腺眼科疾病每四周一次（Q4 W）的前凸反应率的主要终点
2026-03-30 19:16
- REVEAL-1 met the primary endpoint of Q4W proptosis responder rate (PRR) with a highly statistically significant treatment effect.
- Elegrobart Q4W and Q8W achieved clinically meaningful 54% and 63% PRR versus 18% placebo at week 24.
- Complete resolution of diplopia in 51% of patients treated Q4W versus 16% placebo at week 24.
- Elegrobart was generally well tolerated in both dose groups with low rates of hearing impairment.
- REVEAL-2, a phase 3 clinical trial evaluating elegrobart in patients with chronic TED, is on track for topline readout in Q2 2026; BLA submission anticipated in Q1 2027.
- Viridian ended Q4 2025 with $875 million in cash; the company anticipates existing cash, potential near-term milestones from its 2025 royalty agreement, and anticipated commercial revenues from veligrotug and elegrobart if approved, to fund current business plans through profitability.
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