United Therapeutics扩大MannKind协议，开发第二种吸入疗法; MannKind将获得500万美元的预付款、高达3500万美元的里程赛和10%的特许权使用费

 MannKind Corporation (NASDAQ:MNKD) today announced that United Therapeutics Corporation (NASDAQ:UTHR) has exercised its option—granted under the companies' 2018 license and collaboration agreement—to develop a second dry powder inhalation therapy.

The original agreement, which led to U.S. FDA approval of Tyvaso DPI in May 2022, included an option for United Therapeutics to expand the license to include additional active ingredients. Under the terms of the expanded agreement, MannKind will formulate a second investigational molecule using its proprietary Technosphere® platform, and United Therapeutics will conduct preclinical and clinical development.

"Building on the success of Tyvaso DPI, we are proud to deepen our collaboration with United Therapeutics to bring innovative patient-centric inhaled therapies to patients living with pulmonary hypertension," said Michael Castagna, PharmD, Chief Executive Officer of MannKind Corporation. "This next step highlights the strength of our partnership and the versatility of our dry powder formulations and inhalation devices in addressing serious respiratory conditions."

Under the terms of the expanded agreement, MannKind will receive an upfront payment of $5 million and is eligible to receive up to $35 million in development milestones and 10% royalties on net sales of any resulting product.

Formulation and development activities for the new investigational molecule will begin immediately.