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箭头因与萨雷普塔合作而陷入困境

2025-07-21 23:58

  • Arrowhead Pharmaceuticals (NASDAQ:ARWR) is down ~22% since market close on July 18 and the reason could be that the company has several early-stage candidates in partnership with recently belaguered Sarepta Therapeutics (NASDAQ:SRPT).
  • Arrowhead closed July 19 down ~11% and is down another ~11% in late Monday morning trading. 
  • Sarepta and Arrowhead have four phase 1 candidates they are working on together: ARO-DUX4 for facioscapulohumeral muscular dystrophy type 1; ARO-DM1 for myotonic dystrophy type 1; ARO-ATXN2 for spinocerebellar ataxia 2; and ARO-ATXN2 for spinocerebellar ataxia 2    
  • Arrowhead also has two candidates in phase 3, but for cardiometabolic indications.
  • Sarepta closed July 19 down ~36% after the U.S. FDA asked the company to voluntarily halt shipments of its Duchenne muscular dystrophy gene therapy Elevidys due to three patients deaths linked to the treatment. Sarepta has declined to do so. 
  • Earlier Monday, Sarepta disclosed that the FDA had issued clinical holds on trials for several candidates for limb girdle muscular dystrophy. 

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